Litchi (Litchi chinensis Sonn.) flower proanthocyanidin fraction exhibited protective efficacy to suppress nickel-induced expression for vascular endothelial growth factor in HepG2 cells.
Identifieur interne : 000297 ( Main/Exploration ); précédent : 000296; suivant : 000298Litchi (Litchi chinensis Sonn.) flower proanthocyanidin fraction exhibited protective efficacy to suppress nickel-induced expression for vascular endothelial growth factor in HepG2 cells.
Auteurs : Jau-Tien Lin [Taïwan] ; Yuan-Yen Chang [Taïwan] ; Yi-Chen Chen [Taïwan] ; Po-Lin Liao [Taïwan] ; Deng-Jye Yang [Taïwan]Source :
- Journal of food biochemistry [ 1745-4514 ] ; 2019.
Descripteurs français
- KwdFr :
- Cellules HepG2 (MeSH), Expression des gènes (effets des médicaments et des substances chimiques), Extraits de plantes (analyse), Extraits de plantes (isolement et purification), Extraits de plantes (pharmacologie), Facteur de croissance endothéliale vasculaire de type A (génétique), Facteur de croissance endothéliale vasculaire de type A (métabolisme), Fleurs (composition chimique), Humains (MeSH), Litchi (composition chimique), Mitogen-Activated Protein Kinases (génétique), Mitogen-Activated Protein Kinases (métabolisme), Nickel (métabolisme), Phosphatidylinositol 3-kinases (génétique), Phosphatidylinositol 3-kinases (métabolisme), Proanthocyanidines (analyse), Proanthocyanidines (isolement et purification), Proanthocyanidines (pharmacologie), Protéines proto-oncogènes c-akt (génétique), Protéines proto-oncogènes c-akt (métabolisme), Transduction du signal (effets des médicaments et des substances chimiques).
- MESH :
- analyse : Extraits de plantes, Proanthocyanidines.
- composition chimique : Fleurs, Litchi.
- effets des médicaments et des substances chimiques : Expression des gènes, Transduction du signal.
- génétique : Facteur de croissance endothéliale vasculaire de type A, Mitogen-Activated Protein Kinases, Phosphatidylinositol 3-kinases, Protéines proto-oncogènes c-akt.
- isolement et purification : Extraits de plantes, Proanthocyanidines.
- métabolisme : Facteur de croissance endothéliale vasculaire de type A, Mitogen-Activated Protein Kinases, Nickel, Phosphatidylinositol 3-kinases, Protéines proto-oncogènes c-akt.
- pharmacologie : Extraits de plantes, Proanthocyanidines.
- Cellules HepG2, Humains.
English descriptors
- KwdEn :
- Flowers (chemistry), Gene Expression (drug effects), Hep G2 Cells (MeSH), Humans (MeSH), Litchi (chemistry), Mitogen-Activated Protein Kinases (genetics), Mitogen-Activated Protein Kinases (metabolism), Nickel (metabolism), Phosphatidylinositol 3-Kinases (genetics), Phosphatidylinositol 3-Kinases (metabolism), Plant Extracts (analysis), Plant Extracts (isolation & purification), Plant Extracts (pharmacology), Proanthocyanidins (analysis), Proanthocyanidins (isolation & purification), Proanthocyanidins (pharmacology), Proto-Oncogene Proteins c-akt (genetics), Proto-Oncogene Proteins c-akt (metabolism), Signal Transduction (drug effects), Vascular Endothelial Growth Factor A (genetics), Vascular Endothelial Growth Factor A (metabolism).
- MESH :
- chemical , analysis : Plant Extracts, Proanthocyanidins.
- chemical , genetics : Mitogen-Activated Protein Kinases, Proto-Oncogene Proteins c-akt, Vascular Endothelial Growth Factor A.
- chemistry : Flowers, Litchi.
- drug effects : Gene Expression, Signal Transduction.
- genetics : Phosphatidylinositol 3-Kinases.
- chemical , isolation & purification : Plant Extracts, Proanthocyanidins.
- chemical , metabolism : Mitogen-Activated Protein Kinases, Nickel, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Vascular Endothelial Growth Factor A.
- chemical , pharmacology : Plant Extracts, Proanthocyanidins.
- Hep G2 Cells, Humans.
Abstract
The protective efficacy of litchi (Litchi chinensis Sonn.) flower proanthocyanidin fraction (LFPF) composed of (-)-epicatechin and proanthocyanidin A2 against vascular endothelial growth factor (VEGF) generation induced by nickel (Ni) in hepatocellular carcinoma (Hep G2) cells was studied. VEGF is an angiogenic inducer, which promotes tumor angiogenesis, leading to rapid tumor growth and metastasis. VEGF could be substantially induced in the Ni-mediated Hep G2 cells. Through LFPF treatment, the Ni-induced VEGF generation could be suppressed significantly. The inhibition of HIF-1α expression by blocking phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathways, and the suppression of Janus kinase 2 (JAK2)/signal transducers and activators of transcription 3 (STAT 3), and Raf-1 proto-oncogene, serine/threonine kinase (RAF1)/mitogen-activated protein kinase (MEK1/2)/extracellular-signal-regulated kinase (ERK1/2) pathways are important molecular mechanisms for the LFPF action. LFPF should probably reduce the risk of liver cancer in Ni-contaminated environments by inhibiting VEGF expression. PRACTICAL APPLICATIONS: LFPF mainly contained (-)-epicatechin and proanthocyanidin A2. Our results demonstrated that LFPF considerably suppressed the Ni-induced VEGF expression through inhibition of JAK2/STAT 3 and RAF1/MEK1/2/ERK1/2 pathways and prohibited HIF-1α expression through blocking PI3K/AKT/mTOR pathway. Litchi flowers might have the potential to diminish the liver cancer risk in a Ni-contaminated environment through suitable treatment.
DOI: 10.1111/jfbc.12882
PubMed: 31353727
Affiliations:
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xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Education, Chung Shan Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Yuan Yen" sort="Chang, Yuan Yen" uniqKey="Chang Y" first="Yuan-Yen" last="Chang">Yuan-Yen Chang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, School of Medicine, Chung-Shan Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Microbiology and Immunology, School of Medicine, Chung-Shan Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Clinical Laboratory, Chung Shan Medical 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National Yang-Ming University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Deng Jye" sort="Yang, Deng Jye" uniqKey="Yang D" first="Deng-Jye" last="Yang">Deng-Jye Yang</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Food Safety and Health Risk Assessment, National Yang-Ming University, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Food Safety and Health Risk Assessment, National Yang-Ming University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition and Master Program for Food and Drug Safety, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Nutrition and Master Program for Food and Drug Safety, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Food Nutrition and Health Biotechnology, Asia University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of food biochemistry</title><idno type="eISSN">1745-4514</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Flowers (chemistry)</term><term>Gene Expression (drug effects)</term><term>Hep G2 Cells (MeSH)</term><term>Humans (MeSH)</term><term>Litchi (chemistry)</term><term>Mitogen-Activated Protein Kinases (genetics)</term><term>Mitogen-Activated Protein Kinases (metabolism)</term><term>Nickel (metabolism)</term><term>Phosphatidylinositol 3-Kinases (genetics)</term><term>Phosphatidylinositol 3-Kinases (metabolism)</term><term>Plant Extracts (analysis)</term><term>Plant Extracts (isolation & purification)</term><term>Plant Extracts (pharmacology)</term><term>Proanthocyanidins (analysis)</term><term>Proanthocyanidins (isolation & purification)</term><term>Proanthocyanidins (pharmacology)</term><term>Proto-Oncogene Proteins c-akt (genetics)</term><term>Proto-Oncogene Proteins c-akt (metabolism)</term><term>Signal Transduction (drug effects)</term><term>Vascular Endothelial Growth Factor A (genetics)</term><term>Vascular Endothelial Growth Factor A (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Cellules HepG2 (MeSH)</term><term>Expression des gènes (effets des médicaments et des substances chimiques)</term><term>Extraits de plantes (analyse)</term><term>Extraits de plantes (isolement et purification)</term><term>Extraits de plantes (pharmacologie)</term><term>Facteur de croissance endothéliale vasculaire de type A (génétique)</term><term>Facteur de croissance endothéliale vasculaire de type A (métabolisme)</term><term>Fleurs (composition chimique)</term><term>Humains (MeSH)</term><term>Litchi (composition chimique)</term><term>Mitogen-Activated Protein Kinases (génétique)</term><term>Mitogen-Activated Protein Kinases (métabolisme)</term><term>Nickel (métabolisme)</term><term>Phosphatidylinositol 3-kinases (génétique)</term><term>Phosphatidylinositol 3-kinases (métabolisme)</term><term>Proanthocyanidines (analyse)</term><term>Proanthocyanidines (isolement et purification)</term><term>Proanthocyanidines (pharmacologie)</term><term>Protéines proto-oncogènes c-akt (génétique)</term><term>Protéines proto-oncogènes c-akt (métabolisme)</term><term>Transduction du signal (effets des médicaments et des substances chimiques)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Plant Extracts</term><term>Proanthocyanidins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Mitogen-Activated Protein Kinases</term><term>Proto-Oncogene Proteins c-akt</term><term>Vascular Endothelial Growth Factor A</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Extraits de plantes</term><term>Proanthocyanidines</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Flowers</term><term>Litchi</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Fleurs</term><term>Litchi</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gene Expression</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Expression des gènes</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Phosphatidylinositol 3-Kinases</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type A</term><term>Mitogen-Activated Protein Kinases</term><term>Phosphatidylinositol 3-kinases</term><term>Protéines proto-oncogènes c-akt</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Plant Extracts</term><term>Proanthocyanidins</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Extraits de plantes</term><term>Proanthocyanidines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Mitogen-Activated Protein Kinases</term><term>Nickel</term><term>Phosphatidylinositol 3-Kinases</term><term>Proto-Oncogene Proteins c-akt</term><term>Vascular Endothelial Growth Factor A</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type A</term><term>Mitogen-Activated Protein Kinases</term><term>Nickel</term><term>Phosphatidylinositol 3-kinases</term><term>Protéines proto-oncogènes c-akt</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Extraits de plantes</term><term>Proanthocyanidines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Plant Extracts</term><term>Proanthocyanidins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Hep G2 Cells</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cellules HepG2</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The protective efficacy of litchi (Litchi chinensis Sonn.) flower proanthocyanidin fraction (LFPF) composed of (-)-epicatechin and proanthocyanidin A2 against vascular endothelial growth factor (VEGF) generation induced by nickel (Ni) in hepatocellular carcinoma (Hep G2) cells was studied. VEGF is an angiogenic inducer, which promotes tumor angiogenesis, leading to rapid tumor growth and metastasis. VEGF could be substantially induced in the Ni-mediated Hep G2 cells. Through LFPF treatment, the Ni-induced VEGF generation could be suppressed significantly. The inhibition of HIF-1α expression by blocking phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathways, and the suppression of Janus kinase 2 (JAK2)/signal transducers and activators of transcription 3 (STAT 3), and Raf-1 proto-oncogene, serine/threonine kinase (RAF1)/mitogen-activated protein kinase (MEK1/2)/extracellular-signal-regulated kinase (ERK1/2) pathways are important molecular mechanisms for the LFPF action. LFPF should probably reduce the risk of liver cancer in Ni-contaminated environments by inhibiting VEGF expression. PRACTICAL APPLICATIONS: LFPF mainly contained (-)-epicatechin and proanthocyanidin A2. Our results demonstrated that LFPF considerably suppressed the Ni-induced VEGF expression through inhibition of JAK2/STAT 3 and RAF1/MEK1/2/ERK1/2 pathways and prohibited HIF-1α expression through blocking PI3K/AKT/mTOR pathway. Litchi flowers might have the potential to diminish the liver cancer risk in a Ni-contaminated environment through suitable treatment.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31353727</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>26</Day></DateCompleted><DateRevised><Year>2020</Year><Month>08</Month><Day>26</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1745-4514</ISSN><JournalIssue CitedMedium="Internet"><Volume>43</Volume><Issue>7</Issue><PubDate><Year>2019</Year><Month>07</Month></PubDate></JournalIssue><Title>Journal of food biochemistry</Title><ISOAbbreviation>J Food Biochem</ISOAbbreviation></Journal><ArticleTitle>Litchi (Litchi chinensis Sonn.) flower proanthocyanidin fraction exhibited protective efficacy to suppress nickel-induced expression for vascular endothelial growth factor in HepG2 cells.</ArticleTitle><Pagination><MedlinePgn>e12882</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/jfbc.12882</ELocationID><Abstract><AbstractText>The protective efficacy of litchi (Litchi chinensis Sonn.) flower proanthocyanidin fraction (LFPF) composed of (-)-epicatechin and proanthocyanidin A2 against vascular endothelial growth factor (VEGF) generation induced by nickel (Ni) in hepatocellular carcinoma (Hep G2) cells was studied. VEGF is an angiogenic inducer, which promotes tumor angiogenesis, leading to rapid tumor growth and metastasis. VEGF could be substantially induced in the Ni-mediated Hep G2 cells. Through LFPF treatment, the Ni-induced VEGF generation could be suppressed significantly. The inhibition of HIF-1α expression by blocking phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathways, and the suppression of Janus kinase 2 (JAK2)/signal transducers and activators of transcription 3 (STAT 3), and Raf-1 proto-oncogene, serine/threonine kinase (RAF1)/mitogen-activated protein kinase (MEK1/2)/extracellular-signal-regulated kinase (ERK1/2) pathways are important molecular mechanisms for the LFPF action. LFPF should probably reduce the risk of liver cancer in Ni-contaminated environments by inhibiting VEGF expression. PRACTICAL APPLICATIONS: LFPF mainly contained (-)-epicatechin and proanthocyanidin A2. Our results demonstrated that LFPF considerably suppressed the Ni-induced VEGF expression through inhibition of JAK2/STAT 3 and RAF1/MEK1/2/ERK1/2 pathways and prohibited HIF-1α expression through blocking PI3K/AKT/mTOR pathway. Litchi flowers might have the potential to diminish the liver cancer risk in a Ni-contaminated environment through suitable treatment.</AbstractText><CopyrightInformation>© 2019 Wiley Periodicals, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Jau-Tien</ForeName><Initials>JT</Initials><AffiliationInfo><Affiliation>Department of Medical Applied Chemistry, Chung Shan Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Education, Chung Shan Medical University Hospital, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Yuan-Yen</ForeName><Initials>YY</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, School of Medicine, Chung-Shan Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yi-Chen</ForeName><Initials>YC</Initials><AffiliationInfo><Affiliation>Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liao</LastName><ForeName>Po-Lin</ForeName><Initials>PL</Initials><AffiliationInfo><Affiliation>Institute of Food Safety and Health Risk Assessment, National Yang-Ming University, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Deng-Jye</ForeName><Initials>DJ</Initials><Identifier Source="ORCID">0000-0001-8801-4148</Identifier><AffiliationInfo><Affiliation>Institute of Food Safety and Health Risk Assessment, National Yang-Ming University, Taipei, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Nutrition and Master Program for Food and Drug Safety, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>05</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Food Biochem</MedlineTA><NlmUniqueID>7706045</NlmUniqueID><ISSNLinking>0145-8884</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044945">Proanthocyanidins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D042461">Vascular Endothelial Growth Factor A</NameOfSubstance></Chemical><Chemical><RegistryNumber>41743-41-3</RegistryNumber><NameOfSubstance UI="C473740">proanthocyanidin A2</NameOfSubstance></Chemical><Chemical><RegistryNumber>7OV03QG267</RegistryNumber><NameOfSubstance UI="D009532">Nickel</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D051057">Proto-Oncogene Proteins c-akt</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.24</RegistryNumber><NameOfSubstance UI="D020928">Mitogen-Activated Protein Kinases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D035264" MajorTopicYN="N">Flowers</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015870" MajorTopicYN="N">Gene Expression</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056945" MajorTopicYN="N">Hep G2 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032125" MajorTopicYN="N">Litchi</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020928" MajorTopicYN="N">Mitogen-Activated Protein Kinases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009532" MajorTopicYN="N">Nickel</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019869" MajorTopicYN="N">Phosphatidylinositol 3-Kinases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044945" MajorTopicYN="N">Proanthocyanidins</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051057" MajorTopicYN="N">Proto-Oncogene Proteins c-akt</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042461" MajorTopicYN="N">Vascular Endothelial Growth Factor A</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">HepG2 cell</Keyword><Keyword MajorTopicYN="Y">hypoxia inducible factor (HIF)-1α</Keyword><Keyword MajorTopicYN="Y">litchi flower</Keyword><Keyword MajorTopicYN="Y">mechanism</Keyword><Keyword MajorTopicYN="Y">nickel (Ni)</Keyword><Keyword MajorTopicYN="Y">proanthocyanidin</Keyword><Keyword MajorTopicYN="Y">vascular endothelial growth factor (VEGF)</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>12</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>04</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>04</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31353727</ArticleId><ArticleId IdType="doi">10.1111/jfbc.12882</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Lin, Jau Tien" sort="Lin, Jau Tien" uniqKey="Lin J" first="Jau-Tien" last="Lin">Jau-Tien Lin</name></noRegion><name sortKey="Chang, Yuan Yen" sort="Chang, Yuan Yen" uniqKey="Chang Y" first="Yuan-Yen" last="Chang">Yuan-Yen Chang</name><name sortKey="Chang, Yuan Yen" sort="Chang, Yuan Yen" uniqKey="Chang Y" first="Yuan-Yen" last="Chang">Yuan-Yen Chang</name><name sortKey="Chen, Yi Chen" sort="Chen, Yi Chen" uniqKey="Chen Y" first="Yi-Chen" last="Chen">Yi-Chen Chen</name><name sortKey="Liao, Po Lin" sort="Liao, Po Lin" uniqKey="Liao P" first="Po-Lin" last="Liao">Po-Lin Liao</name><name sortKey="Lin, Jau Tien" sort="Lin, Jau Tien" uniqKey="Lin J" first="Jau-Tien" last="Lin">Jau-Tien Lin</name><name sortKey="Yang, Deng Jye" sort="Yang, Deng Jye" uniqKey="Yang D" first="Deng-Jye" last="Yang">Deng-Jye Yang</name><name sortKey="Yang, Deng Jye" sort="Yang, Deng Jye" uniqKey="Yang D" first="Deng-Jye" last="Yang">Deng-Jye Yang</name><name sortKey="Yang, Deng Jye" sort="Yang, Deng Jye" uniqKey="Yang D" first="Deng-Jye" last="Yang">Deng-Jye Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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